Īccording to the earlier definitions of sepsis updated in 2001, sepsis is a constellation of symptoms secondary to an infection that manifests as disruptions in heart rate, respiratory rate, temperature, and white blood cell count. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia. Septic shock is a result of a systemic response to infection or multiple infectious causes. The mortality rate from septic shock is approximately 25–50%. It most commonly affects children, immunocompromised individuals, and the elderly, as their immune systems cannot deal with infection as effectively as those of healthy adults. įrequently, people with septic shock are cared for in intensive care units. It can cause multiple organ dysfunction syndrome (formerly known as multiple organ failure) and death. It may be located in any part of the body, but most commonly in the lungs, brain, urinary tract, skin or abdominal organs. The primary infection is most commonly caused by bacteria, but also may be by fungi, viruses or parasites. This combination is associated with hospital mortality rates greater than 40%. Patients with septic shock can be clinically identified by requiring a vasopressor to maintain a mean arterial pressure of 65 mm Hg or greater and having serum lactate level greater than 2 mmol/L (>18 mg/dL) in the absence of hypovolemia. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defines septic shock as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. Septic shock is a potentially fatal medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism. Thrombocytopenia with purpura on right hand in patient with septic shock Sepsis is one of the most common causes of death in critically ill patients in Intensive Care Units.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |